Document Detail


Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and Whites.
MedLine Citation:
PMID:  22984453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Given the unique role of the corticotrophin-releasing hormone (CRH) system in human fetal development, the aim of our study was to estimate the association of birth weight with DNA sequence variation in three maternal genes involved in regulating CRH production, bioavailability and action: CRH, CRH-Binding Protein (CRH-BP), and CRH type 1 receptor (CRH-R1), respectively, in three racial groups (African-Americans, Hispanics, and non-Hispanic Whites).
METHODS: Our study was carried out on a population-based sample of 575 mother-child dyads. We resequenced the three genes in mouse-human hybrid somatic cell lines and selected SNPs for genotyping.
RESULTS: A significant association was observed in each race between birth weight and maternal CRH-BP SNP genotypes. Estimates of linkage disequilibrium and haplotypes established three common haplotypes marked by the rs1053989 SNP in all three races. This SNP predicted significant birth weight variation after adjustment for gestational age, maternal BMI, parity, and smoking. African American and Hispanic mothers carrying the A allele had infants whose birth weight was on average 254 and 302 grams, respectively, less than infants having C/C mothers. Non-Hispanic White mothers homozygous for the A allele had infants who were on average 148 grams less than those infants having A/C and C/C mothers.
CONCLUSIONS: The magnitudes of the estimates of the birth weight effects are comparable to the combined effects of multiple SNPs reported in a recent meta-analysis of 6 GWAS studies and is quantitatively larger than that associated with maternal cigarette smoking. This effect was persistent across subpopulations that vary with respect to ancestry and environment.
Authors:
Pathik D Wadhwa; Hyagriv N Simhan; Sonja Entringer; Claudia Buss; Roger Smith; Calvin J Hobel; Naveed Farhana; Lawrence Shimmin; James E Hixson; Charles F Sing
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-11
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-17     Completed Date:  2013-03-12     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e43931     Citation Subset:  IM    
Affiliation:
Departments of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America. pwadhwa@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics*
Animals
Birth Weight / genetics*
Carrier Proteins / genetics*
European Continental Ancestry Group / genetics*
Female
Genetic Variation*
Genotype
Hispanic Americans / genetics*
Humans
Infant
Mice
Mothers*
Polymorphism, Single Nucleotide / genetics
Risk Factors
Grant Support
ID/Acronym/Agency:
P01 HD-047609/HD/NICHD NIH HHS; P01 HD047609/HD/NICHD NIH HHS; R01 HD-060628/HD/NICHD NIH HHS; R01 HD060628/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 134773-81-2/corticotropin releasing factor-binding protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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