| Variation in CDKAL1 gene is associated with therapeutic response to sulphonylureas. | |
| | |
MedLine Citation:
|
PMID: 22292718 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of the present pilot pharmacogenetic study was to analyse quantitative effects of sulphonylurea treatment in addition to metformin on parameters of glycaemic control with respect to CDKAL1 genotypes in patients with type 2 diabetes. Effect of 6-month sulphonylurea therapy on glycaemic control according to CDKAL1 genotypes was evaluated in 101 patients with type 2 diabetes who failed to achieve glycaemic control on metformin monotherapy. CDKAL1 rs7756992 polymorphism was determined by melting curve analysis of small amplicon following real-time PCR. After sulphonylurea treatment fasting plasma glucose (FPG) levels were significantly different (p=0.045) among three CDKAL1 genotype groups (AA: n=49; AG: n=36; GG: n=16). In a dominant genetic model, carriers of the G-allele (AG+GG, n=52) achieved significantly lower FPG levels in comparison with patients with the AA genotype (6.90+/-1.08 vs. 7.48+/-1.12 mmol/l, p=0.013). Consequently, adjusted deltaFPG was significantly higher in the AG+GG compared to the AA group (1.48+/-1.51 vs. 1.02+/-1.33 mmol/l, p=0.022). Similar trend was observed for HbA(1c) levels, but the difference between the genotype groups did not reach the level of statistical significance. Relatively small number of included patients is a limitation of the present study. In conclusion, our results suggest that the magnitude of FPG reduction after 6-month sulphonylurea treatment in patients with type 2 diabetes is related to the variation in CDKAL1. |
| | |
Authors:
|
Z Schroner; M Javorský; J Halušková; L Klimčáková; E Babjaková; M Fabianová; E Slabá; M Kozárová; I Tkáč |
Related Documents
:
|
868638 - The fate of intratracheal 14c-guanidinated pancreatic elastase in hamster lung. 10877218 - Serum amyloid a, procalcitonin, and c-reactive protein in early assessment of severity ... 1582958 - Impact of nutrition on pancreatic exocrine and endocrine secretion in ruminants: a review. 3222248 - Feedback regulation of basal pancreatic secretion in humans. 19997558 - Expression-based network biology identifies alteration in key regulatory pathways of ty... 17488998 - The effect of oral health education on dental plaque development and the level of carie... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
|
Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: - ISSN: 1802-9973 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Internal Medicine 4, L. Pasteur University Hospital, Košice, Slovakia. ivantkac@lf.upjs.sk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Liver mitochondrial respiratory function and coenzyme Q content in rats on a hypercholesterolemic di...
Next Document: The content of five sex steroids in human testis.