Document Detail

Variation in body composition determines long-term blood pressure changes in pre-hypertension: the MONICA/KORA (Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Research in the Region of Augsburg) cohort study.
MedLine Citation:
PMID:  20620719     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We studied the relationship between changes in body composition and changes in blood pressure levels.
BACKGROUND: The mechanisms underlying the frequently observed progression from pre-hypertension to hypertension are poorly understood.
METHODS: We examined 1,145 subjects from a population-based survey at baseline in 1994/1995 and at follow-up in 2004/2005. First, we studied individuals pre-hypertensive at baseline who, during 10 years of follow-up, either had normalized blood pressure (PreNorm, n = 48), persistently had pre-hypertension (PrePre, n = 134), or showed progression to hypertension (PreHyp, n = 183). In parallel, we studied predictors for changes in blood pressure category in individuals hypertensive at baseline (n = 429).
RESULTS: After 10 years, the PreHyp group was characterized by a marked increase in body weight (+5.71% [95% confidence interval (CI): 4.60% to 6.83%]) that was largely the result of an increase in fat mass (+17.8% [95% CI: 14.5% to 21.0%]). In the PrePre group, both the increases in body weight (+1.95% [95% CI: 0.68% to 3.22%]) and fat mass (+8.09% [95% CI: 4.42% to 11.7%]) were significantly less pronounced than in the PreHyp group (p < 0.001 for both). The PreNorm group showed no significant change in body weight (-1.55% [95% CI: -3.70% to 0.61%]) and fat mass (+0.20% [95% CI: -6.13% to 6.52%], p < 0.05 for both, vs. the PrePre group).
CONCLUSIONS: After 10 years of follow-up, hypertension developed in 50.1% of individuals with pre-hypertension and only 6.76% went from hypertensive to pre-hypertensive blood pressure levels. An increase in body weight and fat mass was a risk factor for the development of sustained hypertension, whereas a decrease was predictive of a decrease in blood pressure.
Marcello Ricardo Paulista Markus; Jan Stritzke; Ulrike Siewert; Wolfgang Lieb; Andreas Luchner; Angela Döring; Ulrich Keil; Hans-Werner Hense; Heribert Schunkert;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  56     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-08-06     Revised Date:  2011-08-22    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-76     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Medical Clinic II, University of Lübeck Medical School, Lübeck, Germany.
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MeSH Terms
Adipose Tissue / anatomy & histology
Blood Pressure / physiology*
Body Composition*
Body Weight
Cohort Studies
Disease Progression
Follow-Up Studies
Hypertension / physiopathology
Middle Aged
H E Wichmann / ; H Löwel / ; C Meisinger / ; T Illig / ; R Holle / ; J John /
Comment In:
Curr Hypertens Rep. 2011 Aug;13(4):262-4   [PMID:  21556701 ]

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