Document Detail

Variation of human milk oligosaccharides in relation to milk groups and lactational periods.
MedLine Citation:
PMID:  20522272     Owner:  NLM     Status:  MEDLINE    
Human milk oligosaccharides, representing the third largest fraction of human milk, have been assigned important protective functions for newborns acting as bifidogenic substrates or as inhibitory agents towards pathogens. Using high-pH anion-exchange chromatography and an enzyme test kit, twenty oligosaccharides and lactose were determined in milk samples of German women from days 3 to 90 postpartum. Twenty-two secretor mothers with Lewis blood group Le(a - b+) synthesised all twenty oligosaccharides, and could be assigned to milk group 1. Five non-secretor mothers (Le(a+b - )) produced all oligosaccharides with the exception of α1,2-fucosylated compounds (milk group 2), whereas three secretor mothers with blood type Le(a - b - ) lacked α1,4-fucosyloligosaccharides, corresponding to milk group 3. Secretor women of milk groups 1 and 3 synthesised significantly higher amounts of total neutral oligosaccharides and of several total core structures (e.g. lacto-N-tetraose) than non-secretor women. Generally, these oligosaccharides significantly decrease during the first 3 months postpartum. By comparing fucosyloligosaccharides within and among the three milk groups, insight into their biosynthesis could be gained. Six acidic oligosaccharides without fucose residues were detected in milk samples of all mothers. Regression analysis confirmed that total acidic oligosaccharides declined threefold during the study period. Milk samples corresponding to the three milk groups exhibited significant qualitative and quantitative differences during the first 3 months of lactation. It can be assumed that particularly milk of non-secretor women (milk group 2) exerts a modified biological protection in the babies in comparison with milks of secretors (groups 1 and 3).
Stephan Thurl; Manfred Munzert; Jobst Henker; Günther Boehm; Beate Müller-Werner; Jürgen Jelinek; Bernd Stahl
Publication Detail:
Type:  Journal Article     Date:  2010-06-04
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1261-71     Citation Subset:  IM    
Department of Food Technology, Fulda University of Applied Sciences, Marquardstrasse 35, 36039 Fulda, Germany.
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MeSH Terms
Fucose / analysis
Lactation / metabolism*
Lewis Blood-Group System*
Milk, Human / chemistry*
Oligosaccharides / analysis*,  biosynthesis
Regression Analysis
Time Factors
Young Adult
Reg. No./Substance:
0/Lewis Blood-Group System; 0/Oligosaccharides; 3713-31-3/Fucose

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