| Variation of glycinamide ribonucleotide synthetase levels during in vitro aging of human fibroblasts: implications for gene dosage studies. | |
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MedLine Citation:
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PMID: 3762234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of glycinamide ribonucleotide synthetase were monitored in four human fibroblast cell lines, two diploid, one monosomy 21 and one trisomy 21, from early passage number to senescence. In all four lines, enzyme activity increased as the cells aged. Enzyme levels for the diploid versus trisomy 21 cells did not consistently exhibit the expected gene dosage effect. |
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Authors:
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R G Hards; D Patterson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 36 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-11-20 Completed Date: 1986-11-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Carbon-Nitrogen Ligases* Cell Line Diploidy Fibroblasts / enzymology*, physiology Humans Kinetics Ligases / metabolism* Trisomy |
| Grant Support | |
ID/Acronym/Agency:
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AG00029/AG/NIA NIH HHS; HD-17449/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 6.-/Ligases; EC 6.3.-/Carbon-Nitrogen Ligases; EC 6.3.4.13/phosphoribosylamine-glycine ligase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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