| Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. | |
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MedLine Citation:
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PMID: 12213905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aldosterone-to-renin ratio (ARR) is a marker of aldosterone activity in hypertension. We examined the relationship of the ARR to the distribution of two biallelic polymorphisms at the CYP11B2 gene locus. One polymorphism affects a putative steroidogenic factor-1 binding site (-344 T/C) in the 5'-regulatory region, whereas the other marker reflects replacement of the intron-2 from CYP11B2 with that from the neighboring gene encoding 11beta-hydroxylase (CYP11B1; wild-type/conversion). We studied consecutive referrals to the Tayside hypertension clinic in 1998. Because the specificity of ARR (pmol/liter/ng/ml/h) for hyperaldosteronism increases with its threshold, ARRs of at least 750 and 1000 were used. A total of 375 patients were assessed; 86.9% had complete data. There were significant excesses of steroidogenic factor-1 (T) (ARR >/= 750, 0.62 vs. 0.51, P = 0.014; ARR >/= 1000, 0.63 vs. 0.51, P = 0.039) and intron-2 (conversion) (ARR >/= 750, 0.49 vs. 0.41, P = 0.205; ARR >/= 1000, 0.54 vs. 0.41, P = 0.029) alleles in patients with a raised ARR. The odds ratio for a raised ARR was 2.27 [95% confidence interval, 1.01, 5.09; P < 0.05] comparing patients with a homozygous haplotype for these alleles with those without any such alleles, and this risk increased with age. This study supports the notion that there is a genetic component that regulates aldosterone production and that hyperaldosteronism might develop over time in susceptible individuals. |
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Authors:
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Pitt O Lim; Thomas M Macdonald; Christine Holloway; Elaine Friel; Niall H Anderson; Eleanor Dow; Roland T Jung; Eleanor Davies; Robert Fraser; John M C Connell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 87 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-05 Completed Date: 2002-10-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 4398-402 Citation Subset: AIM; IM |
Affiliation:
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Hypertension Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom. limpo@cf.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood* Aldosterone Synthase / genetics* Base Sequence Blood Pressure Creatinine / blood DNA Primers Female Genetic Variation* Genotype Humans Hypertension / blood, enzymology, genetics* Male Middle Aged Polymerase Chain Reaction Potassium / blood Renin / blood* Sodium / blood |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 52-39-1/Aldosterone; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 1.14.15.4/Aldosterone Synthase; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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