Document Detail


A Variation of the Fischer Indolization Involving Condensation of Quinone Monoketals and Aliphatic Hydrazines.
MedLine Citation:
PMID:  23283848     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new twist: A one-pot nitrous acid free, diazonium-free, and transition-metal-free variation of the Fischer indole synthesis has been developed. Condensation of quinone monoketals and aliphatic hydrazine hydrochlorides afforded indoles via intermediate alkylaryldiazenes. This method will complement the classical Fischer indole synthesis by providing indoles in two steps from widely available phenols under mild conditions.
Authors:
Jinzhu Zhang; Zhiwei Yin; Patrick Leonard; Jing Wu; Kate Sioson; Che Liu; Robert Lapo; Shengping Zheng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry and Biochemistry, Hunter College, 695 Park Avenue, New York, NY 10065 (USA); The Graduate Center, The City University of New York, 365 5th Avenue, New York, NY 10016 (USA).
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