Document Detail


Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx.
MedLine Citation:
PMID:  23335232     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Genetically determinedcapacity for NER may modulate both cancer risk and prognosis. Thus, we evaluated associations of seven selected variants in the NER core genes with recurrence risk in 658SCCOP patients treated principally by radiation. The sevenpolymorphisms in the core NERgenes (XPC-rs2228000, XPC-rs2228001, XPD-rs1799793, XPD-rs13181, XPG-rs17655, ERCC1-rs3212986, and XPA-rs1800975)were genotyped using PCR-RFLP methodand log-rank test and multivariable Cox models were used to evaluate the associationsin both dominant and recessive genetic models. In a dominant model, we found that polymorphisms of XPC-rs2228000,XPD-rs1799793, and XPG-rs17655were significantly associated with disease-free survival(log-rank,P =0.014; P = 0.00008; and P = 0.0007, respectively),and these polymorphisms were significantly associated with recurrence risk of SCCOP (HR = 1.6, 95% CI, 1.1-2.3 for XPC-rs2228000; HR =0.4, 95%, 0.3-0.6 for XPD-rs1799793; and HR =0.5, 95% CI, 0.4-0.8 for XPG-rs17655)after multivariable adjustment. Moreover, the borderline significant or significant associations were also found for these three polymorphisms in HPV16/18-positive SCCOP patients (HR= 1.6, 95% CI, 1.0-4.1 for XPC-rs2228000; HR = 0.2, 95%, 0.1-0.5 for XPD-rs1799793; and HR = 0.1, 95% CI, 0.0-0.9 for XPG-rs17655). However, similarly significant associations were not found for these polymorphisms in a recessive model. These findings suggest that polymorphisms of XPC-rs2228000,XPD-rs1799793, and XPG-rs17655in the NER core genes may contribute to recurrence risk of SCCOP, particularly HPV-positive SCCOP, in a dominant but not in a recessive model. However, validation of these results is warranted.
Authors:
Xicheng Song; Erich M Sturgis; Lei Jin; Zhongqiu Wang; Qingyi Wei; Guojun Li
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 UICC.
Affiliation:
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States; Department of Otolaryngology-Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China.
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