Document Detail


Variants in the nestin gene and coronary heart disease.
MedLine Citation:
PMID:  18724036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. METHODS AND RESULTS: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). CONCLUSION: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.
Authors:
Weihua Meng; Chris C Patterson; Christine Belton; Anne Hughes; Pascal P McKeown
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1538-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Institute of Clinical Science, Queen's University Belfast, Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Coronary Disease / genetics*
Female
Humans
Intermediate Filament Proteins / genetics*
Ireland
Male
Middle Aged
Nerve Tissue Proteins / genetics*
Polymorphism, Single Nucleotide*
Chemical
Reg. No./Substance:
0/Intermediate Filament Proteins; 0/Nerve Tissue Proteins; 0/nestin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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