| Variants in the nestin gene and coronary heart disease. | |
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MedLine Citation:
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PMID: 18724036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. METHODS AND RESULTS: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). CONCLUSION: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required. |
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Authors:
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Weihua Meng; Chris C Patterson; Christine Belton; Anne Hughes; Pascal P McKeown |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-25 Completed Date: 2009-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1538-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Institute of Clinical Science, Queen's University Belfast, Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, Northern Ireland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Coronary Disease / genetics* Female Humans Intermediate Filament Proteins / genetics* Ireland Male Middle Aged Nerve Tissue Proteins / genetics* Polymorphism, Single Nucleotide* |
| Chemical | |
Reg. No./Substance:
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0/Intermediate Filament Proteins; 0/Nerve Tissue Proteins; 0/nestin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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