| Variants of the Ankyrin Repeat Domain 6 Gene (ANKRD6) and Muscle and Physical Activity Phenotypes among European-derived American Adults. | |
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MedLine Citation:
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PMID: 22580979 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT:: Ankyrin repeat domain 6 (ANKRD6) is a ubiquitous protein that associates with early development in mammals, and is highly expressed in the brain, spinal cord, and heart of humans. We examined the role of 8 ANKRD6 single nucleotide polymorphisms (SNPs) on muscle performance and habitual physical activity (PA). SNPs were 545 T>A (rs9362667), 485 M>L (rs61736690), 233 T>M (rs2273238), 128 I>L (rs3748085), 631 P>L (rs61739327), 122 Q>E (rs16881983), 197805 G>A (rs9344950), and 710 L>X (NOVEL). Subjects were 922 healthy, untrained European-derived American men (n=376, 23.6±.3 yr, 25.0±.2kg•m) and women (n=546, 23.2±.2 yr, 24.0±.2kg•m). Muscle strength [maximum voluntary contraction (MVC), one repetition maximum (1-RM)] and size [cross-sectional area (CSA)] were assessed before and after 12 wk of unilateral resistance training (RT). A subsample (n = 536, 23.4±0.2 yr, 24.6±0.2 kg•m) completed the Paffenbarger PA Questionnaire. Associations among ANKRD6 genotypes and muscle phenotypes were tested with repeated measure ANCOVA and PA phenotypes with multivariate ANCOVA with age and body mass index as covariates. ANKRD6 122 Q>E associated with increased baseline biceps CSA. ANKRD6 545 A>T and ANKRD6 710 L>X associated with increased 1RM and MVC in response to RT, respectively. ANKRD6 631 P>L associated with increased biceps CSA response to RT and time spent in moderate intensity PA among the total sample and women. ANKRD6 genetic variants associated with the muscle size and strength response to RT and habitual PA levels. Further research is needed to validate our results, and explore mechanisms for the associations we observed. |
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Authors:
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Katherine N Van Deveire; Sarah K Scranton; Mathew A Kostek; Tj Angelopoulos; Pm Clarkson; Pm Gordon; Nm Moyna; Ps Visich; Rf Zoeller; Pd Thompson; J Devaney; H Gordish-Dressman; Ep Hoffman; Cm Maresh; Ls Pescatello |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-10 |
Journal Detail:
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Title: Journal of strength and conditioning research / National Strength & Conditioning Association Volume: - ISSN: 1533-4287 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9415084 Medline TA: J Strength Cond Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Connecticut, Storrs, CT 2University of Central Florida, Orlando, FL 3University of Massachusetts, Amherst, MA 4University of Michigan, Ann Arbor, MI 5Dublin City University, Dublin, Ireland 6Central Michigan University, Mt. Pleasant, MI 7Florida Atlantic University, Boca Raton, FL 8Hartford Hospital, Hartford, CT 9Children's National Medical Center, Washington, DC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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