| Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients. | |
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MedLine Citation:
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PMID: 22049178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM. OBJECTIVE: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients. DESIGN, SETTING, AND PARTICIPANTS: Five hundred seventy-five patients (367 men and 208 women) who received kidney transplants between 1989 and 2007, without a history of diabetes and with a pretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387. RESULTS: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128). CONCLUSION: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner. |
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Authors:
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Eun Seok Kang; Faidon Magkos; Beom Seok Kim; Rihong Zhai; Li Su; Yu Seun Kim; David C Christiani; Hyun Chul Lee; Christos S Mantzoros |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-02 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 97 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-06 Completed Date: 2012-02-27 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E129-35 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330, Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA. edgo@yuhs.ac |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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genetics Adult Diabetes Mellitus / etiology*, genetics Female Follow-Up Studies Gene Frequency Genetic Predisposition to Disease Genotype Humans Kidney Transplantation / adverse effects* Male Middle Aged Polymorphism, Single Nucleotide* / physiology Receptors, Adiponectin / genetics* Sex Factors Transplantation, Homologous |
| Grant Support | |
ID/Acronym/Agency:
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AG032030/AG/NIA NIH HHS; DK58785/DK/NIDDK NIH HHS; DK79929/DK/NIDDK NIH HHS; DK81913/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/ADIPOR1 protein, human; 0/Adiponectin; 0/Receptors, Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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