| Variants of the adenosine A(2A) receptor gene are protective against proliferative diabetic retinopathy in patients with type 1 diabetes. | |
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MedLine Citation:
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PMID: 21088442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The adenosine A(2A) receptor (ADORA(2A)) may ameliorate deleterious physiologic effects associated with tissue injury in individuals with diabetes. We explored associations between variants of the ADORA(2A) gene and proliferative diabetic retinopathy (PDR) in a cohort of patients with type 1 diabetes (T1D). METHODS: The participants were from the Pittsburgh Epidemiology of Diabetes Complications prospective study of childhood-onset T1D. Stereoscopic photographs of the retinal fundus taken at baseline, then biennially, for 10 years were used to define PDR according to the modified Airlie House system. Two tagging single nucleotide polymorphisms (tSNPs; rs2236624-C/T and rs4822489-G/T) in the ADORA(2A) gene were selected using the HapMap (haplotype map) reference database. RESULTS: A significant association was observed between SNP rs2236624 and PDR in the recessive genetic model. Participants homozygous for the T allele displayed a decreased risk of developing prevalent PDR (odds ratio, OR = 0.36; p = 0.04) and incident PDR (hazard ratio = 0.156; p = 0.009), and for all cases of PDR combined (OR = 0.23; p = 0.001). The protective effect of T allele homozygosity remained after adjusting for covariates. Similarly, for SNP rs4822489, an association between PDR and T allele homozygosity was observed following covariate adjustment (OR = 0.55; 95% CI: 0.31-0.92; p = 0.04). CONCLUSION: Genetic variants of ADORA(2A) offer statistically significant protection against PDR development in patients with T1D. |
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Authors:
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Bashira A Charles; Yvette P Conley; Guanjie Chen; Rachel G Miller; Janice S Dorman; Michael B Gorin; Robert E Ferrell; Susan M Sereika; Charles N Rotimi; Trevor J Orchard |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2010-11-19 |
Journal Detail:
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Title: Ophthalmic research Volume: 46 ISSN: 1423-0259 ISO Abbreviation: Ophthalmic Res. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-16 Completed Date: 2011-10-13 Revised Date: 2012-04-11 |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-5635, USA. charlesba@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diabetes Mellitus, Type 1 / genetics* Diabetic Retinopathy / genetics*, prevention & control Female Genotype Humans Male Polymerase Chain Reaction Polymorphism, Single Nucleotide* Prospective Studies Receptor, Adenosine A2A / genetics* Retinal Neovascularization / genetics*, prevention & control Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1F31NR008970-01A2/NR/NINR NIH HHS; R01 DK034818-21/DK/NIDDK NIH HHS; Z01HG200362/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Adenosine A2A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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