Document Detail

Variant translocations of chromosome 22 in Ewing's sarcoma.
MedLine Citation:
PMID:  7509628     Owner:  NLM     Status:  MEDLINE    
Relatively few variant translocations have been reported in primary Ewing's sarcomas (ES). We report two new variant translocations, both of which involve chromosomal rearrangements of 22q12. Cytogenetic studies of tumor cells from a 12-year-old girl revealed a variant translocation, t(7;22)(p22;q12), the second example reported of a simple variant of the 22q12 reciprocal translocation in this type of sarcoma. The identity of this rearrangement was confirmed by in situ hybridization. In addition, a complex translocation was identified in a dysmorphic 15-year-old girl, t(4;11;22)(q21;q24;q12). No previous cases of variant translocations in ES have involved band 7p22 or 4q21, and there are no previous reports of an association between congenital abnormalities and unusual karyotype abnormalities in ES. Both variant translocations conserve the junction on the der (22), providing additional cytogenetic evidence that the sequences on chromosome 22 are critical.
J Squire; M Zielenska; P Thorner; S Tennyson; S Weitzman; K M Pai; H Yeger; Y K Ng; R Weksberg
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  8     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-04-07     Completed Date:  1994-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  190-4     Citation Subset:  IM    
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Child, Preschool
Chromosome Banding
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 22*
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 7
Sarcoma, Ewing's / genetics*
Translocation, Genetic / genetics*

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