| Variable susceptibility to immune complex glomerulonephritis among mice sharing the same major histocompatibility complex. | |
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MedLine Citation:
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PMID: 3793159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three inbred strains of mice were identified which demonstrated different susceptibilities to induction of immune complex glomerulonephritis (ICGN) despite sharing the same major histocompatibility complex haplotype (H-2k). Groups of mice from each of these three strains, B10.BR, CBA and C3H/HeJ, were injected with one of two different dose schedules of horse apoferritin (HAF) for 4 weeks, after which glomerular morphology, immunoglobulin deposition, and serum anti-HAF antibody levels were examined. With either dose schedule, only those mice which demonstrated a high level antibody response developed ICGN and glomerular immunoglobulin deposition. These results suggest that susceptibility to ICGN in this model is related to the level of antigen exposure and to the magnitude of the antibody response, which is not under strict control of the major histocompatibility complex. |
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Authors:
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K R McLeish; G T Stelzer; A F Gohara; J H Wallace |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunological investigations Volume: 15 ISSN: 0882-0139 ISO Abbreviation: Immunol. Invest. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1987-02-19 Completed Date: 1987-02-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8504629 Medline TA: Immunol Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 541-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation Antibody Specificity Antigen-Antibody Complex / immunology* Apoferritins / administration & dosage, immunology Disease Susceptibility Glomerulonephritis / genetics, immunology* H-2 Antigens / genetics, immunology Horses Major Histocompatibility Complex* Male Mice Mice, Inbred CBA / genetics* Mice, Inbred Strains / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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AM 30388/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/H-2 Antigens; 9013-31-4/Apoferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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