Document Detail


Variable positive end-expiratory pressure can maintain oxygenation in experimental acute respiratory distress syndrome induced by oleic acid in dogs.
MedLine Citation:
PMID:  19649399     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The use of positive end-expiratory pressure (PEEP) or lung recruitment maneuvers (RM) to improve oxygenation in acute respiratory distress syndrome (ARDS) is used but it may reduce cardiac output (CO). Intermittent PEEP may avoid these complications. Our objective was to determine if variable PEEP compared with constant PEEP is capable of maintaining arterial oxygenation and minimizing hemodynamic alterations with or without RM. Eighteen dogs with ARDS induced by oleic acid were randomized into three equal groups: group 1, low variable PEEP; group 2, high variable PEEP, and group 3, RM + high variable PEEP. All groups were submitted to constant PEEP, followed by variable PEEP (PEEP was increased from 5 to 10 cmH(2)O in group 1, and from 5 to 18 cmH(2)O in the other two groups). PaO(2) was higher in group 3 (356.2 +/- 65.4 mmHg) than in group 1 (92.7 +/- 29.7 mmHg) and group 2 (228.5 +/- 72.4 mmHg), P < 0.05. PaO(2) was maintained during variable PEEP except in group 2 (318.5 +/- 82.9 at constant PEEP to 228.5 +/- 72.4 at variable PEEP). There was a reduction in CO in group 3 after RM (3.9 +/- 1.1 before to 2.7 +/- 0.5 L*min(-1)*(m(2))(-1) after; P < 0.05), but there was not any difference between constant and variable PEEP periods (2.7 +/- 0.5 and 2.4 +/- 0.7 L*min(-1)*(m(2))(-1); P > 0.05. Variable PEEP is able to maintain PaO(2) when performed in combination with RM in dogs with ARDS. After RM, CO was reduced and there was no relevant difference between the variable and constant PEEP periods.
Authors:
F C Lanza; M C P Damasceno; F Leme; A C Z Yagui; K C Paiva; A Luque; O S Beppu
Related Documents :
11804239 - Positive end expiratory pressure and expiratory flow limitation: a model study.
18835969 - Defining rules for the identification of critical ventilatory events.
9817719 - Effect of different pressure levels on the dynamics of lung collapse and recruitment in...
17082369 - Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired...
17653529 - Assessment of regional lung recruitment and derecruitment during a peep trial based on ...
2160739 - Continuous measurement of atrial volume with an impedance catheter during positive pres...
1599379 - Peripheral and central blood flow in man during cold, thermoneutral, and hot water imme...
1571299 - Effects of exposure to carbon disulphide on low density lipoprotein cholesterol concent...
23635239 - Note: improved sensitivity of magnetic measurements under high pressure in miniature ce...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  42     ISSN:  1414-431X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  731-7     Citation Subset:  IM    
Affiliation:
Disciplina de Pneumologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil. fernanda_lanza@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Circadian cardiac autonomic function in perinatally HIV-infected preschool children.
Next Document:  Salt and insulin sensitivity after short and prolonged high salt intake in elderly subjects.