| Variable optical activation of human cone photoreceptors visualized using a short coherence light source. | |
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MedLine Citation:
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PMID: 20016612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been shown that after a visible stimulus, optical oscillations of nearly all cone photoreceptors can be observed using long coherence length light and in a few cones using short coherence length light. Here, we show that after exposure to a visible stimulus, a short coherence length imaging source reveals light-evoked oscillation signals in a large number of cones. More than 80% of cones in a given retinal area are activated (modulation in the reflectance signal) after stimulation, and the pattern of their activation can be subjectively classified into one of four categories. The application of light-evoked signal detection techniques for in vivo retinal imaging may prove useful for assessing the functional status of cones in normal and diseased retinae. |
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Authors:
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Jungtae Rha; Brett Schroeder; Pooja Godara; Joseph Carroll |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Optics letters Volume: 34 ISSN: 1539-4794 ISO Abbreviation: Opt Lett Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-02 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 3782-4 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Medical College of Wisconsin, 925 North 87th Street,Milwaukee, Wisconsin 53226, USA. jrha@mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Dose-Response Relationship, Radiation Evoked Potentials, Visual / physiology, radiation effects Humans Light Lighting / methods* Photic Stimulation / methods* Radiation Dosage Retinal Cone Photoreceptor Cells / physiology*, radiation effects |
| Grant Support | |
ID/Acronym/Agency:
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EY001931/EY/NEI NIH HHS; EY017607/EY/NEI NIH HHS; R01 EY017607-03/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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