Document Detail


Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension.
MedLine Citation:
PMID:  15785005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gene for natriuretic peptides receptor C (NPRC), which is a candidate susceptibility gene for essential hypertension (EH) or obese hypertension, plays a key role in the regulation of plasma levels and biological effects of natriuretic peptides. The aims of the present study were to find new genetic markers in the 5'-flanking region of the NPRC gene and to assess relationships between variants and phenotypes of EH, including EH in obese patients. Using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis, we discovered a novel six-nucleotide repeat polymorphism located 4 base pairs (bp) upstream of the major transcriptional initiation site. We performed association analysis of this variable number of tandem repeat (VNTR) in 242 EH patients and 212 normotensive controls (NT). Although no significant difference in overall frequency of VNTR was found between NT and EH groups, the blood pressure level of EH patients with the 5/6 genotype was significantly higher in obese subjects. This suggests that the VNTR of the 5'-flanking region of the NPRC gene influences blood pressure levels in obesity-associated hypertension.
Authors:
Noriko Aoi; Masayoshi Soma; Tomohiro Nakayama; Dolkun Rahmutula; Kotoko Kosuge; Yoichi Izumi; Koichi Matsumoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  27     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2005-03-23     Completed Date:  2005-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  711-6     Citation Subset:  IM    
Affiliation:
Division of Kidney and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
5' Flanking Region*
Adult
Alleles
Blood Pressure*
Case-Control Studies
Diastole
Female
Genetic Markers
Humans
Hypertension / etiology*,  genetics,  physiopathology*
Male
Middle Aged
Minisatellite Repeats* / genetics
Obesity / complications*
Phenotype
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Receptors, Atrial Natriuretic Factor / genetics*
Systole
Chemical
Reg. No./Substance:
0/Genetic Markers; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor; EC 4.6.1.2/atrial natriuretic factor receptor C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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