Document Detail


Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia.
MedLine Citation:
PMID:  19895348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease. METHODS: We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages. RESULTS: Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115 pg/ml) compared with normal risk preeclamptic patients (16375 pg/ml). PlGF was consistently low in patients who developed preeclampsia. CONCLUSIONS: Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium.
Authors:
Bonnie K Dwyer; Sacha Krieg; Raymond Balise; Ian R Carroll; Jane Chueh; Nihar Nayak; Maurice Druzin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  705-11     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Santa Clara Valley Medical Center, 751 S. Bascom Ave., San Jose, CA 95128, USA. dwyerbk@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / blood,  metabolism
Case-Control Studies
Female
Gestational Age
Humans
Longitudinal Studies
Pre-Eclampsia / blood,  diagnosis,  etiology,  metabolism*
Pregnancy
Pregnancy Proteins / blood,  metabolism
Receptors, Cell Surface / blood,  metabolism
Risk Factors
Solubility
Vascular Endothelial Growth Factor Receptor-1 / blood,  metabolism*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/ENG protein, human; 0/Pregnancy Proteins; 0/Receptors, Cell Surface; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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