| Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia. | |
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MedLine Citation:
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PMID: 19895348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease. METHODS: We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages. RESULTS: Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115 pg/ml) compared with normal risk preeclamptic patients (16375 pg/ml). PlGF was consistently low in patients who developed preeclampsia. CONCLUSIONS: Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium. |
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Authors:
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Bonnie K Dwyer; Sacha Krieg; Raymond Balise; Ian R Carroll; Jane Chueh; Nihar Nayak; Maurice Druzin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 705-11 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Santa Clara Valley Medical Center, 751 S. Bascom Ave., San Jose, CA 95128, USA. dwyerbk@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / blood, metabolism Case-Control Studies Female Gestational Age Humans Longitudinal Studies Pre-Eclampsia / blood, diagnosis, etiology, metabolism* Pregnancy Pregnancy Proteins / blood, metabolism Receptors, Cell Surface / blood, metabolism Risk Factors Solubility Vascular Endothelial Growth Factor Receptor-1 / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/ENG protein, human; 0/Pregnancy Proteins; 0/Receptors, Cell Surface; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1 |
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