Document Detail

Variable effects of anaesthetics on the ventilatory response to hypoxaemia in man.
MedLine Citation:
PMID:  6802469     Owner:  NLM     Status:  MEDLINE    
We compared the ventilatory response to isocapnic hypoxaemia with a standard response to hyperoxic hypercarbia in human subjects sedated with methoxyflurane, diethyl ether or nitrous oxide, or anaesthetized with methoxyflurane. Compared to the awake state, methoxyflurane 0.1 MAC sedation did not alter either response significantly; methoxyflurane 1.1 MAC anaesthesia depressed both, with a somewhat greater effect on the hypoxaemic response. Diethyl ether 0.1 MAC sedation reduced only the hypoxaemic response. Nitrous oxide 0.1 MAC reduced both hypoxaemic and carbon dioxide responses in parallel. The evidence suggests that all three agents - like thiopentone, halothane and enflurane - can impair the ventilatory response to isocapnic hypoxaemia in man, but that in relation to the carbon dioxide responses, the magnitude of this depressive effect varies. Halothane and enflurane are the most depressant, nitrous oxide and thiopentone the least, with methoxyflurane and diethyl ether appearing to be intermediate in effect.
R L Knill; J L Clement
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian Anaesthetists' Society journal     Volume:  29     ISSN:  0008-2856     ISO Abbreviation:  Can Anaesth Soc J     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  0371163     Medline TA:  Can Anaesth Soc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
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MeSH Terms
Anesthetics / pharmacology*
Anoxia / physiopathology*
Carbon Dioxide / pharmacology
Ether / pharmacology
Gases / metabolism
Methoxyflurane / pharmacology
Nitrous Oxide / pharmacology
Respiration / drug effects*
Reg. No./Substance:
0/Anesthetics; 0/Gases; 0F5N573A2Y/Ether; 142M471B3J/Carbon Dioxide; 30905R8O7B/Methoxyflurane; K50XQU1029/Nitrous Oxide
Comment In:
Can J Anaesth. 2014 Jul;61(7):664-70   [PMID:  24473901 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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