| Variable degradation of factor VIII-related protein in lyophilised concentrates of antihaemophilic factor (AHF). | |
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MedLine Citation:
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PMID: 664567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factor VIII-related properties (coagulant = VIII : C, 'Willebrand' factor = VIII R : WF, antigen = VIII R : AG) are measured in a constant proportion in normal plasma and certain preparations of highly purified factor VIII (relative ratios: 0.5--1.5). We tested these activities in some commercial, lyophilised concentrates of factor VIII and found a variable increase of the ratio VIII R : AG/VIII R : WF. The relative increase of VIII R : AG, and/or loss of VIII R : WF, was attributed to variable degradation of factor VIII-related protein(s) which was directly visualized by electrophoresis on 2.75% polyacrylamide gels in the presence of sodium dodecyl sulphate. |
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Authors:
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T Jakab; R Pflugshaupt; M Furlan; E A Beck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vox sanguinis Volume: 35 ISSN: 0042-9007 ISO Abbreviation: Vox Sang. Publication Date: 1978 Jul-Aug |
Date Detail:
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Created Date: 1978-08-28 Completed Date: 1978-08-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 36-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens
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isolation & purification Electrophoresis, Polyacrylamide Gel Factor VIII / immunology, isolation & purification, metabolism* Freeze Drying Humans |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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