Document Detail

Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution.
MedLine Citation:
PMID:  23334245     Owner:  NLM     Status:  MEDLINE    
Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules. The variable NK cell receptors found in humans are specific to simian primates, in which they have progressively co-evolved with MHC class I molecules. The emergence of the MHC-C gene in hominids drove the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees. By contrast, the human system of MHC-C receptors seems to have been subject to different selection pressures that have acted in competition on the immunological and reproductive functions of MHC class I molecules. We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents.
Peter Parham; Ashley Moffett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-21
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  13     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-03-21     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-44     Citation Subset:  IM    
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MeSH Terms
Biological Evolution*
Evolution, Molecular
Histocompatibility Antigens Class I / genetics,  immunology*,  metabolism
Immunity* / genetics,  immunology
Protein Binding
Protein Stability
Receptors, Natural Killer Cell / genetics,  immunology*,  metabolism
Reproduction* / genetics,  immunology
Grant Support
PG/09/077/27964//British Heart Foundation; R01 AI017892/AI/NIAID NIH HHS; R01 AI022039/AI/NIAID NIH HHS; R01 AI024258/AI/NIAID NIH HHS; R01 AI031168/AI/NIAID NIH HHS; U01 AI090905/AI/NIAID NIH HHS; //British Heart Foundation; //Wellcome Trust
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/Receptors, Natural Killer Cell

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