Document Detail

Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans.
MedLine Citation:
PMID:  16428337     Owner:  NLM     Status:  MEDLINE    
Infarct size (IS) increases with vascular occlusion time, area at risk for infarction, lack of collateral supply, absence of preconditioning, and myocardial demand for O2 supply. ECG S-T segment elevation is used as a measure of severity of ischemia and a surrogate for IS. This study in 50 patients with coronary artery disease undergoing a first 120-s balloon occlusion of a stenosis sought to determine whether S-T segment elevation, corrected for the above-mentioned variables, in the left coronary artery (LCA group, n = 36) is different from that in the right coronary artery (RCA group, n = 14) territory. After consideration of all known determinants of IS, particularly mass at risk and collateral supply, the LCA territory is more sensitive than the RCA region to a 2-min period of myocardial ischemia.
Stefano F De Marchi; Pascal Meier; Philipp Oswald; Christian Seiler
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-20
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  291     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-08-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H351-6     Citation Subset:  IM    
Department of Cardiology, University Hospital, Bern, Switzerland.
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MeSH Terms
Coronary Artery Disease / classification,  complications,  diagnosis*,  physiopathology*
Coronary Vessels / physiopathology*
Electrocardiography / methods*
Ischemic Preconditioning / methods*
Middle Aged
Myocardial Ischemia / classification,  diagnosis*,  etiology,  physiopathology*
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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