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Variability of thiobarbituric acid reacting substances in saliva.
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MedLine Citation:
PMID:  19407359     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Salivary TBARS are a potential marker of oxidative stress in the oral cavity. Previous studies have found increased levels of salivary TBARS in various diseases. The aim of this study was to assess the variability of salivary TBARS in both genders.
SUBJECTS & METHODS: Saliva samples from thirty-eight healthy volunteers (18F & 20M) were collected every day during 30 day period. TBARS levels were measured spectrophotometrically using a high-throughput 96-well plate method. Time series analysis was performed using standard statistical methods.
RESULTS: Repeated measures ANOVA showed a significant variation of salivary TBARS within day and subjects (p < 0.001). The dynamics did not differ between genders. Intraindividual variability was very high in both genders with coefficients of variation of more than 60%. Interindividual variability was higher in men than in women (73% vs. 46%; p < 0.01).
DISCUSSION: The relatively high intraindividual variability indicates that the use of salivary TBARS will be limited to research on a population level, although some informative value might be gained by repeated samplings. Factors influencing the biological variability of salivary TBARS should be identified in further studies.
Michal Behuliak; Roland Pálffy; Roman Gardlík; Július Hodosy; Lukác Halcák; Peter Celec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  26     ISSN:  0278-0240     ISO Abbreviation:  Dis. Markers     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-06-19     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
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MeSH Terms
Biological Markers / analysis*
Oxidative Stress
Saliva / chemistry*
Thiobarbituric Acid Reactive Substances / analysis*
Reg. No./Substance:
0/Biological Markers; 0/Thiobarbituric Acid Reactive Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2009 Hindawi Publishing Corporation.
Received Day: 21 Month: 4 Year: 2009
Accepted Day: 21 Month: 4 Year: 2009
Print publication date: Year: 2009
Electronic publication date: Day: 30 Month: 4 Year: 2009
Volume: 26 Issue: 2
First Page: 49 Last Page: 53
PubMed Id: 19407359
ID: 3833695
Article Id: 175683
DOI: 10.3233/DMA-2009-0606

Variability of Thiobarbituric Acid Reacting Substances in Saliva
Michal Behuliak12
Roland Pálffy12
Roman Gardlík12
Július Hodosy13
Lukáč Halčák4
Peter Celec125*
1BiomeD Research & Publishing Group
2Institute of PathophysiologyFaculty of MedicineComenius UniversityBratislavaSlovak Republic
3Institute of PhysiologyFaculty of MedicineComenius UniversityBratislavaSlovak Republic
4Institute of Medical ChemistryBiochemistry and Clinical BiochemistryFaculty of MedicineComenius UniversityBratislavaSlovak Republic
5Department of Molecular BiologyFaculty of Natural SciencesComenius UniversityBratislavaSlovak Republic
Correspondence: *Peter Celec:

Article Categories:
  • Other

Keywords: Thiobarbituric acid reacting substances, malondialdehyde, saliva, interindividual and intraindividual variability.

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