| Variability of steady-state digoxin kinetics during administration of tablets or capsules. | |
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MedLine Citation:
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PMID: 3948469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An encapsulated solution of digoxin has been repeatedly shown to have greater bioavailability than tablet forms of the drug. It is predicted that such a preparation would show reduced within- and between-patient variability in absorption, as most studies in normal subjects have shown reduced intersubject variation with the capsule. We tested inter- and intrapatient variability during 4-week periods of dosing with digoxin capsules and tablets in 28 subjects with cardiac disease. In the overall group there were no significant differences between the formulations at steady state in between-patient variability in trough serum digoxin concentrations or 24-hour urinary digoxin excretion. Within-patient variability in urinary digoxin excretion was somewhat lower for the capsules. In a subgroup of six patients who excreted significant amounts of cardioinactive bacterial metabolites (digoxin reduction products [DRP]), the mean (+/- SD) percent urinary DRP excretion was less (p less than 0.05) during capsule (20.5% +/- 15.1%) than tablet (34.4% +/- 10.9%) dosing. Within-patient variability in urinary DRP excretion was much greater after tablets than capsules. Certain subgroups of patients should benefit from the enhanced bioavailability of digoxin capsule preparations. |
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Authors:
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B F Johnson; J Lindenbaum; E Budnitz; R Marwaha |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 39 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-04-10 Completed Date: 1986-04-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 306-12 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Aged Atrial Fibrillation / drug therapy Biological Availability Blood Capsules Digoxin / administration & dosage, blood, metabolism*, therapeutic use Evaluation Studies as Topic Female Heart Failure / drug therapy Humans Male Middle Aged Radioimmunoassay Tablets |
| Grant Support | |
ID/Acronym/Agency:
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HL 10608/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Capsules; 0/Tablets; 20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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