| Variability of sputum inflammatory mediators in COPD and Alpha-1-antitrypsin deficiency. | |
| | |
MedLine Citation:
|
PMID: 22700846 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
There is inherent daily variability of sputum inflammatory mediators in stable state patients with usual COPD. The variability of pulmonary inflammation in patients with alpha-1-antitrypsin deficiency (A1ATD) is unknown. The current study aimed to quantify this variability, in comparison to patients with usual COPD, in order to facilitate power calculations for proof of concept trials of putative specific anti-inflammatory agents in both patient groups.Sputum interleukin 8, myeloperoxidase, leukotriene B4 and differential cell counts were measured in 12 patients with usual COPD and 12 patients with A1ATD on 9 occasions over a 1 month period. All samples were taken in the stable clinical state.There was significant daily variability in all measured mediators in all patients. A1ATD patients had higher sputum concentrations of interleukin-8 and leukotriene B4 compared with usual COPD, although lower levels of myeloperoxidase and absolute neutrophil counts. Patients with usual COPD had more intra-patient variability; those with A1ATD demonstrated greater inter-patient variability.There are increased concentrations of pulmonary inflammatory mediators, but fewer sputum neutrophils in A1ATD compared with usual COPD. The daily variability of inflammatory mediators and cell counts was significantly reduced in both patient groups by averaging sequential samples. This can be utilised to perform power calculations for future proof of concept studies; averaging 3 sequential samples appears optimum. |
| | |
Authors:
|
H Stone; G McNab; A M Wood; R A Stockley; E Sapey |
Related Documents
:
|
9408096 - Response of parkinsonian swallowing dysfunction to dopaminergic stimulation. 21894386 - Ocular toxoplasmosis: evaluation of lacrimal - specific secretory iga levels in both pa... 9633706 - Visuomotor control abnormalities in patients with unilateral parkinsonism. 17886616 - Peritoneal dialysis as salvage renal replacement therapy after complete failure of hemo... 6480246 - Differentiation of alcoholic from brain-damaged patients by the psychiatric-organic (p-... 22984006 - Conjugate eye deviation in acute intracerebral hemorrhage: stroke acute management with... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-14 |
Journal Detail:
|
Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Birmingham, Birmingham, B15 2TT, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Universal HIV testing in London TB clinics: cluster randomised controlled trial.
Next Document: Apoptosis in Bovine Viral Diarrhea Virus (BVDV)-Induced Mucosal Disease Lesions: A Histological, Imm...