Document Detail

Variability and reproducibility of carotid structural and functional parameters assessed with transcutaneous ultrasound - Results from the SAPALDIA Cohort Study.
MedLine Citation:
PMID:  24267265     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Carotid intima media thickness (CIMT) and local stiffness are vascular biomarkers of atherosclerotic burden. We investigated the variability and reproducibility of clinically relevant structural (CIMT, lumen diameter) and functional parameters (strain, distensibility, compliance, β-stiffness index, Peterson's elastic modulus and Young's elastic modulus) measured in B-mode ultrasound sequences of the common carotid artery in the second follow up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases In Adults (SAPALDIA3).
METHODS: Ultrasound sequential images were examined twice over a 1 cm segment across at least one heart cycle in 165 SAPALDIA3 participants. To assess variability and reproducibility of structural and functional parameters, individual coefficients of variation (CV), intraclass correlation (ICC), Bland-Altman plots and mixed effect regressions were used.
RESULTS: ICCs of repeated examinations ranged between 0.67 and 0.77 for blood pressure indices, between 0.87 and 0.97 for structural properties and between 0.75 and 0.79 for functional parameters. CV was lowest in structural parameters (1.6-4.6%), followed by blood pressure (5.1-7.9%) and functional indices (11.0-13.1%). Variations in all parameters were predominantly explained by subjects (>74% in functional, >82% in structural properties). Bland-Altman plots for functional indices showed mean and standard deviation of the respective mean value of 4.2(19.6)% for strain, 1.9(24.4)% for distensibility, 2.4(22.2)% for compliance, 3.0(24.4)% for β-stiffness index, 0.9(25.7)% for Peterson's elastic modulus and 1.2(27.9)% for Young's elastic modulus.
CONCLUSION: The results show that SAPALDIA3 measurements of transcutaneous ultrasound examinations have an excellent reproducibility of structural parameters and a good reproducibility of functional indices.
Seraina Caviezel; Julia Dratva; Emmanuel Schaffner; Alexandra Teynor; Manfred W Baumstark; Christian Schindler; Eric de Groot; Luc Burdet; Thomas Rothe; Marco Pons; Jean-Michel Gaspoz; Thierry Rochat; Nino Künzli; Nicole Probst-Hensch; Arno Schmidt-Trucksäss
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Publication Detail:
Type:  Journal Article     Date:  2013-10-18
Journal Detail:
Title:  Atherosclerosis     Volume:  231     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  448-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Institute of Exercise and Health Sciences, Div. Sports and Exercise Medicine, University of Basel, Birsstrasse 320B, 4052 Basel, Switzerland. Electronic address:
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