Document Detail


Variability of lipid hydroperoxides in pregnant and nonpregnant women.
MedLine Citation:
PMID:  10080298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipid peroxidation is thought to be important in numerous disease states, including pregnancy complications. Study of its role requires markers, but the variability of available markers in non-diseased populations has not been well-characterized. We examined the variability over time of blood lipid hydroperoxides, as measured by iodometric analysis, in 49 healthy young women, 21 nonpregnant and 28 pregnant. Lipid hydroperoxides from the same woman were very similar from one day to the next but were less stable over periods of a month or more. The correlation between measurements on consecutive days was 0.98; the correlation between measurements a month or more apart was 0.11. Variability over time was not attributable to seasonal effects or, among the pregnant women, to differences over the course of pregnancy. Knowledge of the variability of this and other markers of oxidative damage enables the development of appropriate study designs.
Authors:
B C Gladen; S Tabacova; D D Baird; R E Little; L Balabaeva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  13     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-05-11     Completed Date:  1999-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Affiliation:
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. gladen@niehs.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Circadian Rhythm
Female
Humans
Lipid Peroxidation*
Lipid Peroxides / blood*
Oxidative Stress
Pregnancy / blood*
Seasons
Time Factors
Chemical
Reg. No./Substance:
0/Lipid Peroxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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