| Variability of lipid hydroperoxides in pregnant and nonpregnant women. | |
MedLine Citation:
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PMID: 10080298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipid peroxidation is thought to be important in numerous disease states, including pregnancy complications. Study of its role requires markers, but the variability of available markers in non-diseased populations has not been well-characterized. We examined the variability over time of blood lipid hydroperoxides, as measured by iodometric analysis, in 49 healthy young women, 21 nonpregnant and 28 pregnant. Lipid hydroperoxides from the same woman were very similar from one day to the next but were less stable over periods of a month or more. The correlation between measurements on consecutive days was 0.98; the correlation between measurements a month or more apart was 0.11. Variability over time was not attributable to seasonal effects or, among the pregnant women, to differences over the course of pregnancy. Knowledge of the variability of this and other markers of oxidative damage enables the development of appropriate study designs. |
Authors:
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B C Gladen; S Tabacova; D D Baird; R E Little; L Balabaeva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 13 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 1999 Jan-Feb |
Date Detail:
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Created Date: 1999-05-11 Completed Date: 1999-05-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Affiliation:
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National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. gladen@niehs.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Circadian Rhythm Female Humans Lipid Peroxidation* Lipid Peroxides / blood* Oxidative Stress Pregnancy / blood* Seasons Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Lipid Peroxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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