| Variability in the subcellular distribution of ion channels increases neuronal diversity. | |
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MedLine Citation:
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PMID: 19299025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The exact location of an ion channel on the axo-somato-dendritic surface of a nerve cell crucially affects its functional impact. Recent high-resolution immunolocalization experiments examining the distribution of GABA and glutamate receptors, voltage-gated potassium and sodium channels and hyperpolarization-activated mixed cation (HCN) channels clearly demonstrate the lack of simple rules concerning their subcellular distribution. For example, the density of HCN1 subunits in pyramidal cells increases 60-fold from soma to distal dendrites but is uniform over the somato-dendritic surface of olfactory bulb external tufted cells and is highest in the axon of cortical and cerebellar basket cells. Such findings highlight the necessity of determining the precise subcellular location and density of each ion channel in every cell type. Here, I suggest that variations in the subcellular distribution of ion channels are previously unrecognized means of increasing neuronal diversity and, thus, the computational power of the brain. |
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Authors:
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Zoltan Nusser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-03-18 |
Journal Detail:
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Title: Trends in neurosciences Volume: 32 ISSN: 0166-2236 ISO Abbreviation: Trends Neurosci. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7808616 Medline TA: Trends Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 267-74 Citation Subset: IM |
Affiliation:
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Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary. nusser@koki.hu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / cytology, metabolism Ion Channels / metabolism* Models, Neurological Neurons / classification, metabolism, ultrasonography* Subcellular Fractions / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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