Document Detail

Variability in the relationship between serum creatinine and creatinine clearance in hypertensives and normotensives with normal renal function.
MedLine Citation:
PMID:  11379457     Owner:  NLM     Status:  MEDLINE    
Variabilities exist in the relationship between serum creatinine (Se-C) and creatinine clearance (CCr) due to the influences of age, muscle mass and gender on creatinine production. We studied this variability in a group of hypertensives (n = 62, 30 male, age 44 +/- 7 years) and normotensives (n = 90, 47 male, age 42 +/- 10 years) with normal renal function (Se-C < 1.5 mg/dL). There was a wide scatter of CCr about each Se-C value. Se-C was higher in males than females and in hypertensives than normotensives, but the differences were not statistically significant. Mean Se-C for the whole group was 0.91 +/- 0.23 mg/dL and corresponded to CCr of 93 +/- 23 mL/min and 93 +/- 21 mL/min before and after adjustment to a body surface area (BSA) of 1.73 m2. Adjusted CCr was significantly lower in hypertensives than normotensives in males (86 +/- 20 mL/min Vs 99 +/- 21 mL/min, P < 0.01) and females (84 +/- 19 mL/min Vs 96 +/- 19 mL/min, P < 0.01). Crude CCr was significantly higher in men than women (P < 0.05) in the whole group but not significantly in the normotensive or hypertensive subgroups. After adjustment, the differences diminished and became insignificant in the whole group. Some subgroups had identical mean Se-C values but different adjusted CCr. A particular Se-C value did not always indicate a particular CCr. Adjustment of CCr to 1.73 m2 BSA reduced the variability between Se-C and CCr and the difference between the genders. CCr showed significant difference in renal function between subgroups where Se-C did not.
S Kadiri; S O Ajayi
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Publication Detail:
Type:  Comparative Study; Journal Article; Validation Studies    
Journal Detail:
Title:  African journal of medicine and medical sciences     Volume:  29     ISSN:  0309-3913     ISO Abbreviation:  Afr J Med Med Sci     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2001-05-29     Completed Date:  2001-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801013     Medline TA:  Afr J Med Med Sci     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Dept. of Medicine, University College Hospital, Ibadan, Nigeria.
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MeSH Terms
Bias (Epidemiology)
Case-Control Studies
Confounding Factors (Epidemiology)
Creatinine / blood*,  metabolism*
Glomerular Filtration Rate*
Hypertension / blood*,  classification,  etiology,  metabolism*
Kidney Function Tests / methods*,  standards*
Metabolic Clearance Rate
Middle Aged
Severity of Illness Index
Sex Characteristics
Reg. No./Substance:

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