Document Detail

Variability in measurements of blood glucose response to foods in human subjects is not reduced after a standard breakfast.
MedLine Citation:
PMID:  19410974     Owner:  NLM     Status:  MEDLINE    
Measurements of blood glucose response to food are highly variable. We determined whether within-individual variability in data for blood glucose responses were reduced if individuals consumed a standard meal 2 hours before testing and investigated the effect of serving size. Blood glucose responses to muesli and macaroni cheese were determined in 13 individuals by taking 2 fasting capillary blood samples. Food was then consumed, and capillary blood samples were taken every 15 minutes for the first hour and every 30 minutes for the second hour. The incremental area under the blood glucose response curve was determined, and glycemic glucose equivalents (GGEs) were calculated. The GGE values were not significantly different whether the muesli and macaroni cheese were fed fasting or after a standard breakfast (29.2 vs 34.5 g for muesli and 11.0 vs 14.6 g for macaroni cheese). Within-individual coefficients of variation were not significantly different whether the food was consumed fasting or after a standard breakfast (24.9% and 32.5% for muesli and 38.1% and 59.4% for macaroni cheese). Differences in GGE between measured and estimated half serving size for macaroni cheese were 0.8 g (P = .6) and for muesli, 3 g (P = .2); for the double serving size for macaroni cheese, 1.7 g (P = .7); and for muesli, 6.7 g (P = .06). The GGE values for foods and variability in blood glucose response within individuals were not significantly different whether individuals fasted or consumed a standard breakfast before testing. However, blood glucose levels tended to differ significantly after consumption of the double serving size of muesli compared with other serving sizes.
Alison J Wallace; Sarah L Eady; Jinny A Willis; Russell S Scott; John A Monro; Chris M Frampton
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition research (New York, N.Y.)     Volume:  29     ISSN:  1879-0739     ISO Abbreviation:  Nutr Res     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303331     Medline TA:  Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
New Zealand Institute for Plant and Food Research Limited, Private Bag 4704, Christchurch 8140, New Zealand.
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MeSH Terms
Area Under Curve
Blood Glucose / metabolism*
Dietary Carbohydrates / administration & dosage,  metabolism*
Dietary Fats
Glycemic Index*
Middle Aged
Reproducibility of Results
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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