| Variability in body protein loss during protracted, severe caloric restriction: role of triiodothyronine and other possible determinants. | |
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MedLine Citation:
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PMID: 6383009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six morbidly obese subjects were maintained in a metabolic ward for 64 days on liquid diets providing 600 to 800 kcal/day. Three received protein at a level of 1.5 g/kg desirable weight per day. The other three were given an identical diet in which half the protein was replaced by carbohydrate. Because there were no significant differences in either mean protein or mean fat losses between the two groups, the data on all six subjects were combined. Over the 64 days, the mean weight loss (+/- SEM) of the subjects per 1000 kcal deficit was 174.3 +/- 25.5 g. The composition of this weight loss was 36.0% water, 58.9% fat, and 5.1% protein. Although the rate of fat loss was relatively constant throughout the study, wide interindividual variations in cumulative protein (nitrogen) deficit were observed. Total nitrogen losses per subject ranged from 90.5 to 278.7 g. Cumulative nitrogen loss during the first 16 days tended to correlate negatively with initial mean fat cell size and positively with initial lean body mass. Most notable was the strong negative correlation between the size of the decrease in serum triiodothyronine over the 64-day study and the magnitude of the concurrent cumulative N deficit. During severe caloric restriction, one's ability to decrease circulating serum triiodothyronine levels may be critical to achievement of an adaptational decrease in body protein loss. |
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Authors:
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M U Yang; T B van Itallie |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 40 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-10-03 Completed Date: 1984-10-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 611-22 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Adult Basal Metabolism Body Composition Body Weight Diet, Reducing* Dietary Carbohydrates / administration & dosage Dietary Proteins / administration & dosage Energy Intake Energy Metabolism Food, Formulated* Humans Insulin / blood Male Nitrogen / metabolism Obesity / diet therapy* Proteins / metabolism* Triiodothyronine / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AM-26687/AM/NIADDK NIH HHS; AM-26688/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Proteins; 11061-68-0/Insulin; 6893-02-3/Triiodothyronine; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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