Document Detail


Variability in absorption lag time of pyridoxal phosphate under fasting and pre- and post-meal conditions.
MedLine Citation:
PMID:  7993988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inter-individual variations in the absorption lag time of pyridoxal phosphate were determined after administration of an enteric-coated tablet (EC) or a plain capsule (PC) to 113 healthy volunteers under fasting, pre-meal, and post-meal conditions. The absorption lag time of pyridoxal phosphate was assessed from the urinary excretion of 4-pyridoxic acid after administration of EC and PC. Significantly larger lag times after administration of both formulations were observed under post-meal conditions than under pre-meal conditions (0.477 +/- 0.315 h versus 0.081 +/- 0.086 h for PC and 1.995 +/- 1.345 h versus 1.064 +/- 1.327 h for EC), indicating that the mean gastric emptying rates of both a solution and a tablet were delayed after food intake. The lag time for PC showed little inter-individual variation with (0-1.2 h) or without food (0-0.25 h), whereas that for EC showed markedly large inter-individual variation, from 0.25 to 2.63 h (median, 1.5 h) in the fasting condition, from 0.25 to > 5.5 h (median 0.25 h) under pre-meal conditions, and from 0.25 to > 5.5 h (median 1.25 h) under post-meal conditions. The effect of food on the gastric emptying rate of a solution appears to be almost uniform, whereas that for a tablet is so unpredictable that a reliable absorption rate for an enteric-coated tablet cannot be expected, particularly under pre- and post-meal conditions.
Authors:
H Takahashi; H Ogata; N Nagai; K Sugito; H Shimamura
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  15     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-17     Completed Date:  1995-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  505-17     Citation Subset:  IM    
Affiliation:
Department of Biopharmaceutics, Meiji College of Pharmacy, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Oral
Adult
Biological Availability
Capsules
Chromatography, High Pressure Liquid
Drug Delivery Systems
Eating / physiology*
Fasting / metabolism*
Female
Gastric Emptying / physiology
Humans
Male
Middle Aged
Pyridoxal Phosphate / administration & dosage,  pharmacokinetics*
Pyridoxic Acid / urine*
Tablets, Enteric-Coated
Chemical
Reg. No./Substance:
0/Capsules; 0/Tablets, Enteric-Coated; 54-47-7/Pyridoxal Phosphate; 82-82-6/Pyridoxic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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