Document Detail

Variability in cadence during forced cycling predicts motor improvement in individuals with Parkinson's disease.
MedLine Citation:
PMID:  23144045     Owner:  NLM     Status:  MEDLINE    
Variability in severity and progression of Parkinson's disease symptoms makes it challenging to design therapy interventions that provide maximal benefit. Previous studies showed that forced cycling, at greater pedaling rates, results in greater improvements in motor function than voluntary cycling. The precise mechanism for differences in function following exercise is unknown. We examined the complexity of biomechanical and physiological features of forced and voluntary cycling and correlated these features to improvements in motor function as measured by the Unified Parkinson's Disease Rating Scale (UPDRS). Heart rate, cadence, and power were analyzed using entropy signal processing techniques. Pattern variability in heart rate and power were greater in the voluntary group when compared to forced group. In contrast, variability in cadence was higher during forced cycling. UPDRS Motor III scores predicted from the pattern variability data were highly correlated to measured scores in the forced group. This study shows how time series analysis methods of biomechanical and physiological parameters of exercise can be used to predict improvements in motor function. This knowledge will be important in the development of optimal exercise-based rehabilitation programs for Parkinson's disease.
Angela L Ridgel; Hassan Mohammadi Abdar; Jay L Alberts; Fred M Discenzo; Kenneth A Loparo
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-24
Journal Detail:
Title:  IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society     Volume:  21     ISSN:  1558-0210     ISO Abbreviation:  IEEE Trans Neural Syst Rehabil Eng     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-15     Completed Date:  2014-01-07     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101097023     Medline TA:  IEEE Trans Neural Syst Rehabil Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  481-9     Citation Subset:  IM    
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MeSH Terms
Diagnosis, Computer-Assisted / methods*
Exercise Test / methods*
Movement Disorders / diagnosis*,  physiopathology,  rehabilitation*
Oscillometry / methods*
Parkinson Disease / diagnosis*,  physiopathology,  rehabilitation*
Reproducibility of Results
Sensitivity and Specificity
Task Performance and Analysis*
Therapy, Computer-Assisted / methods*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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