Document Detail


Variability in the COMT gene and modification of the risk of schizophrenia conferred by cannabis consumption.
MedLine Citation:
PMID:  23034243     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The risk of schizophrenia conferred by cannabis has recently been proposed to be modulated by the Val158Met polymorphism (rs4680) at the COMT gene. To date, these findings have not been replicated in independent samples. MATERIAL AND METHODS: We tested the potential gene-by-environment interaction between Val158Met genotype at the COMT gene and previous use of cannabis in schizophrenia in 192 healthy controls and 91 inpatients with DSM-IV schizophrenia. The functional COMT Val158Met polymorphism was analyzed using TaqMan technology. Cannabis use was measured by taking into account the frequency of intake during the previous month. Logistic regression models were used to test the interaction between genetic and environment factors. RESULTS: Cannabis use was strongly associated with the case condition (p<0.0001). The Val158Met polymorphism at the COMT gene was not associated with schizophrenia, although Val/Val homozygosity tended to be more frequent in the case group than in the control group (34% vs 27%; OR=1.39; 95% CI, 0.78-2.47). Finally, in women we found a non-significant trend toward the association when we tested for the interaction between cannabis use, the number of Val alleles and susceptibility to schizophrenia (p=0.152). CONCLUSIONS: Our results tend to support recent findings suggesting that the Val158Met polymorphism at the COMT gene modifies the risk of schizophrenia conferred by cannabis use. In our study, this possible effect was only detected in women.
Authors:
Blanca Gutiérrez; Margarita Rivera; Lourdes Obel; Kathryn McKenney; Rafael Martínez-Leal; Esther Molina; Montse Dolz; Susana Ochoa; Judith Usall; Josep Maria Haro; Miguel Ruiz-Veguilla; Francisco Torres; Jorge Cervilla
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-9-25
Journal Detail:
Title:  Revista de psiquiatria y salud mental     Volume:  2     ISSN:  1989-4600     ISO Abbreviation:  Rev Psiquiatr Salud Ment     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528851     Medline TA:  Rev Psiquiatr Salud Ment     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  89-94     Citation Subset:  -    
Copyright Information:
Copyright © 2009 Sociedad Española de Psiquiatría and Sociedad Española de Psiquiatría Biológica. Published by Elsevier Espana. All rights reserved.
Affiliation:
CIBERSAM Universidad de Granada, Granada, España; Instituto de Neurociencias Federico Olóriz, Centro de Investigaciones Biomédicas, Universidad de Granada, Granada, España. Electronic address: blancag@ugr.es.
Vernacular Title:
Variabilidad en el gen COMT y modificación del riesgo de esquizofrenia conferido por consumo de cannabis.
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