Document Detail

Variability of immunologic and clinical features in patients with rheumatoid arthritis studied over 24 hours.
MedLine Citation:
PMID:  8350328     Owner:  NLM     Status:  MEDLINE    
Disease activity measures in patients with rheumatoid arthritis (RA) are influenced by many factors. Bedrest has been long recognized to effect decreased disease activity. In addition, most patients note maximal levels of pain and stiffness in the early morning hours with improvement in the afternoon. Cytokines and hormones with circadian rhythms may also contribute to variability in disease status during the day. Our purpose was to investigate variability of clinical and immunologic measures over a 24-h period of hospitalization in patients with RA. Production of rheumatoid factors and immunoglobulins, joint counts and questionnaire evaluations were measured 3 to 6 times over a 24-h period of hospitalization in 10 patients with RA who were not receiving steroids or second line drugs. Total joint counts were significantly decreased as soon as 4 h after admission, and continued to decrease during the 24-h period of observation. Significant decreases in mononuclear cell proliferation and antibody synthesis were also observed. Our findings are consistent with the presence of decreased levels of immunostimulatory mediators in hospitalized patients especially during late afternoon or evening hours.
N J Olsen; R H Brooks; D Furst
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  20     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-14     Completed Date:  1993-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  940-3     Citation Subset:  IM    
Department of Medicine, Vanderbilt University, Nashville, TN 37232.
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MeSH Terms
Activities of Daily Living
Arthritis, Rheumatoid / immunology*,  physiopathology
Bed Rest
Circadian Rhythm*
Cytokines / blood
Hormones / blood
Immunoglobulins / biosynthesis
Leukocytes, Mononuclear / immunology
Lymphocyte Activation
Middle Aged
Pain Measurement
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Hormones; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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