Document Detail

Variability of fibrinogen measurements in post-myocardial infarction patients. Results from the AIRGENE study center Augsburg.
MedLine Citation:
PMID:  22399014     Owner:  NLM     Status:  MEDLINE    
Elevated fibrinogen levels are strongly and consistently associated with incident coronary heart disease (CHD). A possible causal contribution of fibrinogen in the pathway leading to atherothrombotic cardiovascular disease complications has been suggested. However, for implementation in clinical practice, data on validity and reliability, which are still scarce, are needed that are still scarce, especially in subjects with a history of CHD. For the present study, levels of plasma fibrinogen were measured in 200 post-myocardial infarction (post-MI) patients aged 39-76 years, with approximately six blood samples collected at monthly intervals between May 2003 and March 2004, giving a total of 1,144 samples. Inter-individual variability (between-subject variance component, VCb and coefficient of variation, CVb), intra-individual and analytical variability (VCw+a and CVw+a), intraclass correlation coefficient (ICC) and the number of measurements required for an ICC of 0.75 were estimated to assess the reliability of serial fibrinogen measurements. Mean fibrinogen concentration of all subjects over all samples was 3.34 g/l (standard deviation 0.67). Between-subject variation for fibrinogen was VCb = 0.34 (CVb'=17.5%) whereas within-subject and analytical variation was estimated as VCw+a = 0.14 (CVw+a=11.0%). The variation was mainly explained by between-subject variability, shown by the proportion of total variance of 71.3%. Two different measurements were required to reach sufficient reliability, if subjects with extreme values were not excluded. The present study indicates a fairly good reproducibility of serial individual fibrinogen measurements in post-MI subjects.
Jens Baumert; Mahir Karakas; Sonja Greven; Regina Rückerl; Annette Peters; Wolfgang Koenig
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2012-03-08
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  107     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-08-27     Revised Date:  2012-10-31    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  895-902     Citation Subset:  IM    
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Europe / epidemiology
Fibrinogen / metabolism*
Longitudinal Studies
Middle Aged
Myocardial Infarction / blood*,  epidemiology
Nephelometry and Turbidimetry
Predictive Value of Tests
Reproducibility of Results
Risk Assessment
Risk Factors
Time Factors
Reg. No./Substance:
0/Biological Markers; 9001-32-5/Fibrinogen

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