Document Detail

Variability of effect of positive end expiratory pressure.
MedLine Citation:
PMID:  1096847     Owner:  NLM     Status:  MEDLINE    
Mechanical ventilation with positive end expiratory pressure (PEEP) has been reported to produce prompt improvement in oxygeneration when used to treat acute respiratory failure. Reports of the effect of PEEP on cardiac output have been conflicting. We studied 14 patients and found that, although mean values of arterial oxygen tension (PaO2) increased as PEEP increased, on eight occasions in the acute studies and three in the elective studies, it fell as PEEP was increased. On five occasions the fall in PaO2 was associated with an increased shunt. Arterial pressure did not, on the average, change at any level of PEEP, but in 13 of 30 measurements it fell by more than 20% and necessitated curtailment of the study at blood pressure levels of less than 50 torr. Since these effects of PEEP cannot be predicted, careful patient monitoring is essential when ventilation with PEEP is utilized.
W G Horton; F W Cheney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  110     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-10-11     Completed Date:  1975-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Hemoglobins / analysis
Middle Aged
Oxygen / blood,  therapeutic use
Oxygen Consumption
Oxyhemoglobins / analysis
Positive-Pressure Respiration*
Respiratory Insufficiency / therapy
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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