| Variability of blood pressure in dialysis patients: a new marker of cardiovascular risk. | |
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MedLine Citation:
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PMID: 22419232 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Hemodialysis patients have a high cardiovascular mortality, and hypertension is the most prevalent treatable risk factor. We aimed to assess the predictive significance of dialysis-to-dialysis variability in blood pressure in hemodialysis patients. Methods: We performed a historical cohort study in 1,088 prevalent hemodialysis patients, followed up for 5 years. The risk of cardiovascular death was determined in relation to dialysis-to-dialysis variability in blood pressure, maximum blood pressure and pulse pressure. Results: Variability in blood pressure was a predictor of cardiovascular death (hazard ratio [HR] = 1.242; 95% confidence interval [95% CI], 1.004-1.537; p=0.046). Also age (HR=1.021; 95% CI, 1.011-1.048; p=0.049), diabetes (HR=1.134; 95% CI, 1.128-1.451; p=0.035), creatinine (HR=0.837; 95% CI, 0.717-0.977; p=0.024) and albumin (HR=0.901; 95% CI, 0.821-0.924; p=0.022) influenced mortality. Maximum blood pressure and pulse pressure did not show any effect on cardiovascular death. Conclusion: Dialysis-to-dialysis variability in blood pressure is a predictor of cardiovascular mortality in hemodialysis patients, and blood pressure variability may be used in managing hypertension and predicting outcomes in dialysis patients. |
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Authors:
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Biagio Di Iorio; Lucia Di Micco; Serena Torraca; Maria Luisa Sirico; Pasquale Guastaferro; Luigi Chiuchiolo; Filippo Nigro; Antonietta De Blasio; Paolo Romano; Andrea Pota; Roberto Rubino; Luigi Morrone; Teodoro Lopez; Francesco Gaetano Casino |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-15 |
Journal Detail:
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Title: Journal of nephrology Volume: - ISSN: 1724-6059 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: 0 Citation Subset: - |
Affiliation:
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Division of Nephrology, "A. Landolfi" Hospital, Solofra, Avellino - Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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