Document Detail

Variability of average SUV from several hottest voxels is lower than that of SUVmax and SUVpeak.
MedLine Citation:
PMID:  24895030     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To assess variability of the average standard uptake value (SUV) computed by varying the number of hottest voxels within an (18)F-fluorodeoxyglucose ((18)F-FDG)-positive lesion. This SUV metric was compared with the maximal SUV (SUVmax: the hottest voxel) and peak SUV (SUVpeak: SUVmax and its 26 neighbouring voxels).
METHODS: Twelve lung cancer patients (20 lesions) were analysed using PET dynamic acquisition involving ten successive 2.5-min frames. In each frame and lesion, average SUV obtained from the N = 5, 10, 15, 20, 25 or 30 hottest voxels (SUVmax-N ), SUVmax and SUVpeak were assessed. The relative standard deviations (SDrs) from ten frames were calculated for each SUV metric and lesion, yielding the mean relative SD from 20 lesions for each SUV metric (SDr N , SDrmax and SDrpeak), and hence relative measurement error and repeatability (MEr-R).
RESULTS: For each N, SDr N was significantly lower than SDrmax and SDrpeak. SDr N correlated strongly with N: 6.471 × N (-0.103) (r = 0.994; P < 0.01). MEr-R of SUVmax-30 was 8.94-12.63 % (95 % CL), versus 13.86-19.59 % and 13.41-18.95 % for SUVmax and SUVpeak respectively.
CONCLUSIONS: Variability of SUVmax-N is significantly lower than for SUVmax and SUVpeak. Further prospective studies should be performed to determine the optimal total hottest volume, as voxel volume may depend on the PET system.
KEY POINTS: • PET imaging provides functional parameters of (18) F-FDG-positive lesions, such as SUVmax and SUVpeak. • Averaging SUV from several hottest voxels (SUVmax- N ) is a further SUV metric. • Variability of SUVmax- N is significantly lower than SUVmax and SUVpeak variability. • SUVmax- N should improve SUV accuracy for predicting outcome or assessing treatment response. • An optimal total hottest volume should be determined through further prospective studies.
E Laffon; F Lamare; H de Clermont; I A Burger; R Marthan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-4
Journal Detail:
Title:  European radiology     Volume:  -     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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