| Variability of Urinary Phthalate Metabolite and Bisphenol A Concentrations before and during Pregnancy. | |
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MedLine Citation:
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PMID: 22262702 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Gestational phthalate and bisphenol A (BPA) exposure may increase the risk of adverse maternal/child health outcomes, but there is little data on the variability of urinary biomarkers before and during pregnancy. Objective: We characterized the variability of urinary phthalate metabolite and BPA concentrations before and during pregnancy and the ability of a single spot-urine sample to classify average gestational exposure. Methods: We collected 1,001 urine samples before and during pregnancy from 137 women who were partners in couples attending a Boston fertility clinic and had a live birth. Women provided spot-urine samples before (n>2) and during (n>2) pregnancy. We measured urinary concentrations of monoethyl phthalate (MEP), mono-n-butyl phthalate (MBP), mono-iso-butyl phthalate (MiBP), monobenzyl phthalate (MBzP), four metabolites of di-(2-ethylhexyl) phthalate (DEHP) and BPA. After adjusting for specific-gravity, we characterized biomarker variability using intraclass correlation coefficients (ICC) and conducted several surrogate category analyses to determine whether a single spot-urine sample could adequately classify average gestational exposure. Results: Concentrations of most phthalate metabolites and BPA were higher during pregnancy than before pregnancy. Variability was higher during pregnancy than before pregnancy for BPA and MBzP, but similar during and before pregnancy for MBP, MEP, and ΣDEHP. During pregnancy, MEP (ICC:0.50) and MBP (ICC:0.45) were less variable than BPA (ICC:0.12), MBzP (ICC:0.25), and ΣDEHP metabolites (ICC:0.08). Surrogate analyses suggested that a single spot-urine sample may reasonably classify MEP and MBP concentrations during pregnancy, but >1 sample may be necessary for MBzP, DEHP, and BPA. Conclusions: Urinary phthalate metabolites and BPA concentrations were variable before and during pregnancy, but the magnitude of variability was biomarker specific. A single spot-urine sample adequately classified MBP and MEP concentrations during pregnancy. The present results may be related to unique features of the women studied and replication in other pregnancy cohorts is recommended. |
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Authors:
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Joe M Braun; Kristen W Smith; Paige L Williams; Antonia M Calafat; Katharine Berry; Shelley Ehrlich; Russ Hauser |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Environmental health perspectives Volume: - ISSN: 1552-9924 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Harvard University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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