Document Detail


Variability of Plasma Homovanillic Acid Over 13 Months in Patients with Schizophrenia; Relationship with the Clinical Response and the Wisconsin Card Sort Test.
MedLine Citation:
PMID:  21475956     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the present study we have measured, on a monthly basis, the concentration of plasma homovanillic acid (pHVA) in schizophrenic patients during 13 months of their pharmacological treatment. The average pHVA values of each patient were within the range of 7.30-17.70 ng/ml and the coefficients of variation for each patient (CV %) were within the range of 13-33%. Half of the patients that showed higher pHVA CV% values also showed higher scores on the Brief Psychiatric Rating Scale at the beginning of the study, and improved more after 6 months, when compared to the remaining 50% with lower CV% values. There was no significant relationship between the scores of the Wisconsin Card Sort Test and the concentration or the CV% of the pHVA of each patient. A greater variability in the pHVA may be associated with a greater plasticity of the dopaminergic system and a better clinical response.
Authors:
Mercedes Zumárraga; Miguel A González-Torres; Aurora Arrue; Ricardo Dávila; Wendy Dávila; Lucía Inchausti; Lucía Pérez-Cabeza; Aránzazu Fernández-Rivas; Sonia Bustamante; Nieves Basterreche; José Guimón
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-8
Journal Detail:
Title:  Neurochemical research     Volume:  -     ISSN:  1573-6903     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departamento de Investigación Neuroquímica, Red de Salud Mental de Bizkaia, Servicio Vasco de Salud, Arteaga Auzoa, 45, 48170, Zamudio, Bizkaia, Spain, mercedes.zumarragaortiz@osakidetza.net.
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