| Variability of G1 gene of hantaviruses occurring in the Hubei Province, P.R. China from 1985 to 2000. | |
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MedLine Citation:
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PMID: 15929399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied variability of G1 gene of hantaviruses occurring in the Hubei province, P.R. China. Serum samples were collected from 229 patients with hemorrhagic fever with renal syndromes (HFRS) during 1985--1989 and 1996--2000 and were tested by RT-PCR for the presence of Hantaan and Seoul viruses (HTNVs, SEOVs) and by restriction fragment length polymorphism (RFLP) analysis for the respective pattern. Out of 229 sera 166 (72.5%) were hantavirus-positive by RT-PCR, including 124 from 1985--1989 and 42 from 1996--2000, with HTNVs in majority (80.1%) and SEOVs in minority (19.9%). By RFLP analysis, four types of RFLP pattern were recognized. In the 133 HTNV isolates the A pattern was most predominant (62.5%), while the remaining patterns B, C, and D were present in minority. This kind of the RFLP pattern distribution was observed regardless the year of virus isolation. In contrast, only one type of RFLP pattern was obtained from 33 SEOVs, but this was different from that of R22 virus. Our results indicate that temporal factor, represented by years 1985--2000 seems to be too short to affect markedly the genetic makeup of the hantaviruses investigated. |
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Authors:
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Q Li; Z Q Yang; H Qu; H Xiao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta virologica Volume: 49 ISSN: 0001-723X ISO Abbreviation: Acta Virol. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-06-02 Completed Date: 2005-09-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370401 Medline TA: Acta Virol Country: Slovakia |
Other Details:
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Languages: eng Pagination: 51-7 Citation Subset: IM |
Affiliation:
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National Key Laboratory of Virology, Institute of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged China Evolution Hantaan virus / genetics*, isolation & purification Hemorrhagic Fever with Renal Syndrome / virology* Humans Middle Aged Molecular Epidemiology Polymorphism, Genetic* Polymorphism, Restriction Fragment Length RNA, Viral / genetics Reverse Transcriptase Polymerase Chain Reaction Seoul virus / genetics*, isolation & purification Viral Envelope Proteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral; 0/Viral Envelope Proteins; 0/glycoprotein G1, Hantavirus |
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