Document Detail

Variability of 3D arterial geometry and dynamics, and its pathologic implications.
MedLine Citation:
PMID:  12122274     Owner:  NLM     Status:  MEDLINE    
Geometric parameters and features vary within the vasculature. Furthermore, at any given anatomic site, there are substantial variations in geometry among individuals. These variations can contribute to a corresponding variability in the hemodynamic environment and, to the extent that hemodynamics affects the atherosclerotic process, the progress of vascular disease. Measurements of the geometry and wall morphometry of post-mortem human coronary arteries demonstrate a relationship between these variables that supports the notion that geometric variations can contribute to a corresponding variability in the local rate of progression of arterial disease. The dynamic geometry of the coronary arteries also varies from site to site and among individuals, and this variability too may play a role in the epidemiology of coronary artery disease.
Morton H Friedman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biorheology     Volume:  39     ISSN:  0006-355X     ISO Abbreviation:  Biorheology     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372526     Medline TA:  Biorheology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  513-7     Citation Subset:  IM    
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
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MeSH Terms
Arteries / pathology,  physiopathology
Coronary Disease / blood,  pathology*,  physiopathology
Coronary Vessels / pathology*,  physiopathology
Disease Susceptibility
Risk Factors
Grant Support

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