| Varenicline: progress in smoking cessation treatment. | |
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MedLine Citation:
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PMID: 17685891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Varenicline is the first pharmacological aid for smoking cessation treatment to be approved in almost a decade. Varenicline is an alpha4beta2 nicotinic acetylcholine receptor partial agonist. It may assist those who wish to quit smoking by producing partial activation at nicotinic receptors to ease craving and withdrawal symptoms; and by simultaneously blocking the effects of nicotine from cigarettes smoked, thereby reducing the satisfaction of continued smoking. The effectiveness of varenicline as an aid for smoking cessation has been demonstrated in several clinical trials versus placebo and sustained release bupropion. In addition, varenicline is well tolerated and has an acceptable safety profile. As an aid for smoking cessation, varenicline offers progress in the treatment of tobacco dependence. |
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Authors:
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Elbert D Glover; Jessica M Rath |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 8 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-09 Completed Date: 2007-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 1757-67 Citation Subset: IM |
Affiliation:
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University of Maryland College Park School of Public Health, Department of Public & Community Health, College Park, MD 20742, USA. eglover1@umd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzazepines / metabolism, therapeutic use* Humans Quinoxalines / metabolism, therapeutic use* Receptors, Nicotinic / metabolism Smoking / drug therapy*, metabolism, trends* Smoking Cessation / methods* |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Quinoxalines; 0/Receptors, Nicotinic; 0/varenicline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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