| Vanishing bile duct syndrome associated with azithromycin in a 62-year-old man. | |
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MedLine Citation:
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PMID: 19906050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vanishing bile duct syndrome is a severe cholestatic disease associated with toxic effects of medications. Stevens-Johnson syndrome is a hypersensitivity disorder that may also be caused by medications. We present a case of a 62-year-old male patient who developed vanishing bile duct syndrome a month after Stevens-Johnson syndrome. These adverse drug reactions were associated with the use of azithromycin (500 mg daily for 3 days). The patient was initially treated for Stevens-Johnson syndrome with steroids, antihistamines and proton pump inhibitors and fully recovered. However, a month after the beginning of Stevens-Johnson syndrome, he developed vanishing bile duct syndrome and was treated with steroids, ursodeoxycholic acid, antihistamines and tacrolimus. Unfortunately, the treatment was unsuccessful and he was listed for liver transplantation which was performed 7 months after the beginning of jaundice. This is the first case of vanishing bile duct syndrome associated with the use of azithromycin and one of few that reports vanishing bile duct syndrome and Stevens-Johnson syndrome co-occurrence. |
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Authors:
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Danica Juricic; Juricic Danica; Irena Hrstic; Hrstic Irena; Davor Radic; Radic Davor; Mate Skegro; Skegro Mate; Marijana Coric; Coric Marijana; Boris Vucelic; Vucelic Boris; Igor Francetic; Francetic Igor |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-11-09 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: 106 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-08 Completed Date: 2010-03-10 Revised Date: 2010-08-04 |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
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Languages: eng Pagination: 62-5 Citation Subset: IM |
Affiliation:
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Division of Clinical Pharmacology, Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia. danica.juricic@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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adverse effects* Azithromycin / adverse effects* Bile Duct Diseases / chemically induced* Cholestasis / chemically induced* Humans Male Middle Aged Stevens-Johnson Syndrome / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 83905-01-5/Azithromycin |
| Comments/Corrections | |
Erratum In:
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Basic Clin Pharmacol Toxicol. 2010 Aug;107(2):700 Note: Danica, Juricic [corrected to Juricic, Danica]; Irena, Hrstic [corrected to Harstic, Irena]; Davor, Radic [corrected to Radic, Davor]; Mate, Skegro [corrected to Skegro, Mate]; Marijana, Coric [corrected to Coric, Marijana]; Boris, Vucelic [corrected to Vucelic, Boris]; Igor, Francetic [corrected to Francetic, Igor] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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