| Vanilloid receptor loss is independent of the messenger plasticity that follows systemic resiniferatoxin administration. | |
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MedLine Citation:
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PMID: 8782884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resiniferatoxin (RTX) depletes vanilloid (capsaicin) receptors from lumbar dorsal root ganglia (DRG) of the rat. In addition, RTX causes changes in neuropeptide and nitric oxide synthase expression in lumbar DRG neurons, similar to those described following axotomy; this latter phenomenon is referred to as messenger plasticity. These findings suggested that vanilloid receptor loss may be part of the plasticity that follows RTX treatment. Here we show that vanilloid receptor expression, as detected by [3H]RTX autoradiography, is not changed in lumbar DRGs of axotomized rats, nor is it altered in a rat model (chronic constriction injury) of neuropathic pain. Thus, the in vivo expression of vanilloid receptors detected by specific [3H]RTX binding does not require the presence of intraaxonally transported trophic factors such as nerve growth factor. We conclude that messenger plasticity and vanilloid receptor loss are mediated by distinct mechanisms. |
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Authors:
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T Farkas-Szallasi; G J Bennett; P M Blumberg; T Hökfelt; J M Lundberg; A Szallasi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 719 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1996 May |
Date Detail:
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Created Date: 1997-02-04 Completed Date: 1997-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 213-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Karolinska Institute, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Capsaicin* Diterpenes / pharmacology* Female Galanin / analysis Ganglia, Spinal / cytology, drug effects*, enzymology Lumbosacral Region Neuronal Plasticity / drug effects* Neurotoxins / pharmacology* Nitric Oxide Synthase / biosynthesis Rats Rats, Sprague-Dawley Receptors, Drug / analysis, drug effects* Vasoactive Intestinal Peptide / analysis |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/Neurotoxins; 0/Receptors, Drug; 37221-79-7/Vasoactive Intestinal Peptide; 404-86-4/Capsaicin; 57444-62-9/resiniferatoxin; 88813-36-9/Galanin; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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