Document Detail

Vane blood-bathed technique reveals the significance of adrenergic reaction in myocardial infarction.
MedLine Citation:
PMID:  20631408     Owner:  NLM     Status:  MEDLINE    
Using the blood-bathed technique of Vane we induced acute coronary occlusion in the dog and subsequently detected adrenaline release into the circulatory system, determined the rate of release and documented its significance for induction of cardiac arrhythmias. In the intact anesthetized dog, adrenaline excess of the magnitude released after coronary occlusion was sufficient to injure the healthy myocardium and to induce unfavorable metabolic systemic alterations. Subsequently, clinical research has documented that a serious clinical course of acute myocardial infarction is associated not only with enhanced excretion of catecholamines but also with augmentation of plasma renin activity and aldosterone levels. The positive therapeutic effect of aldosterone antagonists in acute myocardial infarction has been documented. The clinical value of our results, which were obtained in experimental and clinical studies, was later confirmed in multi-center trials.
Krystyna Herbaczyńska-Cedro; Leszek Ceremuzyński
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  62     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  457-61     Citation Subset:  IM    
Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, PL 02-106 Warszawa, Poland.
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MeSH Terms
Arrhythmias, Cardiac / metabolism*
Catecholamines / blood
Epinephrine / blood,  metabolism*
Heart / innervation
Heart Conduction System / physiopathology
Myocardial Infarction / metabolism*,  physiopathology
Myocardial Ischemia / metabolism*
Myocardium / metabolism*
Receptors, Adrenergic / metabolism*
Sympathetic Nervous System / physiopathology
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic; 51-43-4/Epinephrine

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