| Vancomycin-supplemented impacted bone allografts in infected hip arthroplasty. Two-stage revision results. | |
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MedLine Citation:
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PMID: 15773637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone allografts can store and release high levels of vancomycin. We present our results of a two-stage treatment for infected hip arthroplasty with acetabular and femoral impaction grafting using vancomycin-loaded allografts. We treated 29 patients (30 hips) by removal of the implants, meticulous debridement, parenteral antibiotic therapy and second-stage reconstruction using vancomycin-supplemented impacted bone allografts and a standard, cemented Charnley femoral component. The mean follow-up was 32.4 months (24 to 60). Infection control was obtained in 29 cases (re-infection rate of 3.3%; 95% confidence interval 0.08 to 17) without evidence of progressive radiolucent lines, demarcation or graft resorption. One patient had a further infection ten months after revision caused by a different pathogen. Associated post-operative complications were one traumatic periprosthetic fracture at 14 months, a single dislocation in two hips and four displacements of the greater trochanter. Vancomycin-supplemented allografts restored bone stock and provided sound fixation with a low incidence of further infection. |
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Authors:
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M A Buttaro; R Pusso; F Piccaluga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of bone and joint surgery. British volume Volume: 87 ISSN: 0301-620X ISO Abbreviation: J Bone Joint Surg Br Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-18 Completed Date: 2005-03-29 Revised Date: 2010-11-10 |
Medline Journal Info:
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Nlm Unique ID: 0375355 Medline TA: J Bone Joint Surg Br Country: England |
Other Details:
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Languages: eng Pagination: 314-9 Citation Subset: AIM; IM |
Affiliation:
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The Hip Surgery Unit, Institute of Orthopaedics Carlos E. Ottolenghi Italian Hospital, Buenos Aires, Argentina. cadera@hospitalitaliano.org.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Bacterial Agents / administration & dosage* Arthritis / surgery Arthroplasty, Replacement, Hip / methods* Bone Transplantation / methods* Female Follow-Up Studies Graft Survival Hip Injuries / surgery Humans Male Middle Aged Osteonecrosis / surgery Osteosarcoma / surgery Prosthesis-Related Infections / prevention & control*, radiography Retrospective Studies Transplantation, Homologous Vancomycin / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 1404-90-6/Vancomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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