| Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients. | |
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MedLine Citation:
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PMID: 22660225 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims. To determine the extent of vancomycin removal and vancomycin pharmacokinetics in septic patients with AKI using daily hemodialysis with polysulphone high-flux and low-flux membrane. Methods. Five patients received 6 h daily dialysis with low-flux polysulphone membrane, four patients with high-flux polysulphone membrane. Vancomycin was administered over the last hour of dialysis. The maintenance dose was adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Results. Median percentage of vancomycin removal by low-flux membrane dialysis was 17% (8 - 38%) and by high-flux membrane dialysis was 31% (13-43%). Vancomycin clearance was only moderately higher in high-flux membrane dialysis (median 3.01 l/h, range 2.34-3.5 l/h) compared to low-flux dialysis (median 2.48 l/h, range 0.53-5.68 l/h) in the first day of the study. About two-fold higher vancomycin clearance in high-flux dialysis (median 3.62 l/h, range 1.37-5.07 l/h) was observed on the second day of the study than low-flux dialysis (median 1.74 l/h, range 0.75-30.94 l/h). Conclusions. Both high-flux and low-flux membrane dialysis remove considerable amounts of vancomycin in critically ill septic patients with AKI. Application of vancomycin after each dialysis was required to maintain therapeutic concentrations. |
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Authors:
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Nadezda Petejova; Arnost Martinek; Jana Zahalkova; Jana Duricova; Hana Brozmanova; Karel Urbanek; Milan Grundmann; Ivana Kacirova |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-30 |
Journal Detail:
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Title: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Volume: - ISSN: 1213-8118 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-6-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140142 Medline TA: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Faculty of Medicine, University of Ostrava and University Hospital Ostrava, Czech Republic. petejova@seznam.cz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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