Document Detail

Vancomycin-induced linear IgA disease with autoantibodies to BP180 and LAD285.
MedLine Citation:
PMID:  11736908     Owner:  NLM     Status:  MEDLINE    
Linear IgA disease (LAD) is an acquired autoimmune subepidermal bullous disease characterized by the linear deposition of IgA at the basement membrane zone. A minority of cases are induced by drugs, of which the most frequently implicated is vancomycin. The target antigens in idiopathic LAD are heterogeneous, but have not previously been reported in vancomycin-induced LAD. We report three cases, and in two of these we investigated the target antigens. In both we identified IgA antibodies to LAD285 and IgA and IgG antibodies (dual response) to BP180.
R A Palmer; G Ogg; J Allen; A Banerjee; K S Ryatt; R Ratnavel; F Wojnarowska
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  145     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2001-12-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  816-20     Citation Subset:  IM    
Department of Dermatology, Royal South Hants Hospital, Southampton SO14 OYG, UK.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / adverse effects*
Autoantibodies / analysis*
Autoantigens / immunology
Autoimmune Diseases / chemically induced*
Carrier Proteins*
Collagen / immunology
Cytoskeletal Proteins*
Drug Eruptions / etiology*,  immunology
Immunoglobulin A / analysis*
Nerve Tissue Proteins*
Non-Fibrillar Collagens*
Skin / immunology
Skin Diseases, Vesiculobullous / chemically induced*,  immunology
Vancomycin / adverse effects*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Autoantibodies; 0/Autoantigens; 0/Carrier Proteins; 0/Cytoskeletal Proteins; 0/DST protein, human; 0/Immunoglobulin A; 0/Nerve Tissue Proteins; 0/Non-Fibrillar Collagens; 0/collagen type XVII; 1404-90-6/Vancomycin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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